| # | Eastern Conference | MP | W | D | L | G | GD | Pts | Form |
|---|---|---|---|---|---|---|---|---|---|
| 1. | Louisville City | 15 | 10 | 4 | 1 | 26:11 | 15 | 34 | |
| 2. | Charleston | 15 | 7 | 3 | 5 | 22:18 | 4 | 24 | |
| 3. | Hartford Athletic | 15 | 7 | 2 | 6 | 27:22 | 5 | 23 | |
| 4. | North Carolina | 15 | 5 | 3 | 7 | 16:20 | -4 | 18 | |
| 5. | Loudoun | 15 | 5 | 3 | 7 | 19:25 | -6 | 18 | |
| 6. | Pittsburgh | 15 | 4 | 4 | 7 | 14:16 | -2 | 16 | |
| 7. | Birmingham | 15 | 3 | 7 | 5 | 23:27 | -4 | 16 | |
| 8. | Rhode Island | 15 | 4 | 3 | 8 | 14:20 | -6 | 15 | |
| 9. | Miami FC | 15 | 4 | 3 | 8 | 13:22 | -9 | 15 | |
| 10. | Detroit | 15 | 3 | 6 | 6 | 15:23 | -8 | 15 | |
| 11. | Tampa Bay | 15 | 4 | 2 | 9 | 17:24 | -7 | 14 | |
| 12. | Indy Eleven | 15 | 3 | 2 | 10 | 17:26 | -9 | 11 | |
| # | Western Conference | MP | W | D | L | G | GD | Pts | Form |
| 1. | FC Tulsa | 15 | 6 | 6 | 3 | 21:16 | 5 | 24 | |
| 2. | Sacramento Republic | 15 | 7 | 2 | 6 | 21:14 | 7 | 23 | |
| 3. | New Mexico | 15 | 7 | 2 | 6 | 19:21 | -2 | 23 | |
| 4. | Phoenix Rising | 15 | 5 | 6 | 4 | 21:25 | -4 | 21 | |
| 5. | El Paso | 15 | 4 | 6 | 5 | 16:22 | -6 | 18 | |
| 6. | Oakland Roots | 15 | 4 | 5 | 6 | 29:33 | -4 | 17 | |
| 7. | San Antonio | 15 | 4 | 5 | 6 | 16:21 | -5 | 17 | |
| 8. | Colorado Springs | 15 | 3 | 5 | 7 | 20:33 | -13 | 14 | |
| 9. | Lexington | 15 | 3 | 3 | 9 | 11:26 | -15 | 12 | |
| 10. | Orange County SC | 15 | 2 | 4 | 9 | 14:24 | -10 | 10 | |
| 11. | Las Vegas Lights | 15 | 1 | 5 | 9 | 9:33 | -24 | 8 | |
| 12. | Monterey Bay | 15 | 1 | 4 | 10 | 8:22 | -14 | 7 |