| # | Eastern Conference | MP | W | D | L | G | GD | Pts | Form |
|---|---|---|---|---|---|---|---|---|---|
| 1. | Louisville City | 30 | 22 | 7 | 1 | 56:19 | 37 | 73 | |
| 2. | Charleston | 30 | 19 | 5 | 6 | 62:32 | 30 | 62 | |
| 3. | North Carolina | 30 | 13 | 6 | 11 | 40:39 | 1 | 45 | |
| 4. | Hartford Athletic | 30 | 13 | 5 | 12 | 48:36 | 12 | 44 | |
| 5. | Pittsburgh | 30 | 12 | 8 | 10 | 32:28 | 4 | 44 | |
| 6. | Loudoun | 30 | 12 | 6 | 12 | 45:48 | -3 | 42 | |
| 7. | Rhode Island | 30 | 10 | 8 | 12 | 29:29 | 0 | 38 | |
| 8. | Detroit | 30 | 9 | 10 | 11 | 33:35 | -2 | 37 | |
| 9. | Indy Eleven | 30 | 10 | 5 | 15 | 44:52 | -8 | 35 | |
| 10. | Tampa Bay | 30 | 9 | 7 | 14 | 43:50 | -7 | 34 | |
| 11. | Miami FC | 30 | 8 | 6 | 16 | 29:44 | -15 | 30 | |
| 12. | Birmingham | 30 | 5 | 12 | 13 | 36:50 | -14 | 27 | |
| # | Western Conference | MP | W | D | L | G | GD | Pts | Form |
| 1. | FC Tulsa | 30 | 16 | 9 | 5 | 50:30 | 20 | 57 | |
| 2. | New Mexico | 30 | 14 | 6 | 10 | 45:41 | 4 | 48 | |
| 3. | Sacramento Republic | 30 | 13 | 9 | 8 | 44:27 | 17 | 48 | |
| 4. | El Paso | 30 | 10 | 11 | 9 | 47:45 | 2 | 41 | |
| 5. | San Antonio | 30 | 11 | 7 | 12 | 39:38 | 1 | 40 | |
| 6. | Phoenix Rising | 30 | 9 | 13 | 8 | 48:48 | 0 | 40 | |
| 7. | Orange County SC | 30 | 10 | 9 | 11 | 44:45 | -1 | 39 | |
| 8. | Colorado Springs | 30 | 10 | 7 | 13 | 35:47 | -12 | 37 | |
| 9. | Lexington | 30 | 9 | 9 | 12 | 31:42 | -11 | 36 | |
| 10. | Oakland Roots | 30 | 8 | 8 | 14 | 42:52 | -10 | 32 | |
| 11. | Monterey Bay | 30 | 7 | 8 | 15 | 27:45 | -18 | 29 | |
| 12. | Las Vegas Lights | 30 | 6 | 9 | 15 | 23:50 | -27 | 27 |